abstract：OBJECTIVE:To investigate the regulative effect of microRNA-338-3p on colorectal carcinoma cell invasion and migration. METHODS:The microRNA-338-3p expression pattern of colorectal carcinoma tissues and cell lines was detected by real-time reverse transcriptase polymerase chain reaction. The protein level of smoothened...

journal_title：Japanese journal of clinical oncology

authors： Xue Q,Sun K,Deng HJ,Lei ST,Dong JQ,Li GX

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:In Japan, population-based cancer incidence data are reported several years behind the latest year of cancer mortality data. To bridge this gap, we aimed to determine a short-term projection method for cancer incidence. METHODS:Data between 1985 and 2007 were obtained from the population-based cancer registr...

journal_title：Japanese journal of clinical oncology

authors： Katanoda K,Kamo K,Saika K,Matsuda T,Shibata A,Matsuda A,Nishino Y,Hattori M,Soda M,Ioka A,Sobue T,Nishimoto H

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The consultation fee for outpatient radiotherapy was newly introduced in the national health insurance system in Japan in April 2012. We conducted a survey on the use of this consultation fee and its effect on clinical practices. METHODS:The health insurance committee of the Japanese Society of Therapeutic R...

journal_title：Japanese journal of clinical oncology

authors： Igaki H,Onishi H,Nakagawa K,Dokiya T,Nemoto K,Shigematsu N,Nishimura Y,Hiraoka M,Japanese Society for Therapeutic Radiology and Oncology Health Insurance Committee.

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:In Japan, there had been no prospective clinical studies conducted in terms of modified FOLFOX6 + bevacizumab therapy. We performed a post-marketing Phase II multicenter clinical study to examine the efficacy and safety of this regimen as first-line therapy for Japanese patients with advanced/recurrent colore...

journal_title：Japanese journal of clinical oncology

authors： Nishina T,Takano Y,Denda T,Yasui H,Takeda K,Ura T,Esaki T,Okuyama Y,Kondo K,Takahashi Y,Sugiyama Y,Muro K

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Studies have suggested that bevacizumab has shown activity against various pediatric solid tumors. We, therefore, conducted a Phase I study of bevacizumab plus irinotecan in Japanese children with recurrent, progressive or refractory solid tumors. METHODS:The starting dose was bevacizumab 10 mg/kg over 60-90...

journal_title：Japanese journal of clinical oncology

authors： Okada K,Yamasaki K,Tanaka C,Fujisaki H,Osugi Y,Hara J

更新日期：2013-11-01 00:00:00

abstract：:Endometrial stromal sarcoma is known to be a hormone-dependent tumor. Efficacy of hormonal therapy including high-dose progestins, aromatase inhibitors or gonadotropin-releasing hormone analogs has been reported. We report a case of recurrent endometrial stromal sarcoma, the tumor cells of which were strongly positive...

journal_title：Japanese journal of clinical oncology

authors： Akashi D,Todo Y,Shimada C,Okamoto K,Minobe S,Kato H

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:This study aimed to describe the health behaviors of cancer survivors in the Republic of Korea and to compare them with the health behaviors of two control groups: (i) individuals with no history of cancer but with other chronic diseases and (ii) individuals with no history of cancer or other chronic diseases...

journal_title：Japanese journal of clinical oncology

authors： Oh MG,Han MA,Park J,Ryu SY,Park CY,Choi SW

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To retrospectively examine the outcomes of hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannomas. METHODS:Twenty-five patients with 26 vestibular schwannomas were treated with hypofractionated stereotactic radiation therapy using a CyberKnife. The vestibular sc...

journal_title：Japanese journal of clinical oncology

authors： Morimoto M,Yoshioka Y,Kotsuma T,Adachi K,Shiomi H,Suzuki O,Seo Y,Koizumi M,Kagawa N,Kinoshita M,Hashimoto N,Ogawa K

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:For several decades, radiotherapy has been widely used to treat metastatic vertebral tumors. This study was designed to assess the feasibility and early clinical outcomes of high-dose radiotherapy to treat such tumors, using helical tomotherapy. METHODS:Between June 2009 and December 2011, 51 sites in 36 pat...

journal_title：Japanese journal of clinical oncology

authors： Lee DS,Kwak YK,Jeong SM,Song JH,Kang YN,Lee SN,Jang HS,Kim YS,Yoon SC,Choi BO

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:The CpG island methylator phenotype is strongly associated with poor survival in neuroblastomas. Neuroblastomas with the CpG island methylator phenotype include almost all neuroblastomas with MYCN amplification, and, even among neuroblastomas without MYCN amplification, have worse prognosis. At the same time,...

journal_title：Japanese journal of clinical oncology

authors： Asada K,Watanabe N,Nakamura Y,Ohira M,Westermann F,Schwab M,Nakagawara A,Ushijima T

更新日期：2013-06-01 00:00:00

abstract：:The joint international symposium of the 22nd Hiroshima Cancer Seminar and the 4th Japanese Association for RNA Interference focused on a pivotal role of microRNAs in carcinogenesis, progression and therapy of human cancer. Mammalian immune regulator MCPIP1 (Zc3h12a) RNase acts as a novel suppressor of microRNA activi...

journal_title：Japanese journal of clinical oncology

authors： Tahara H,Kay MA,Yasui W,Tahara E

更新日期：2013-05-01 00:00:00

abstract：:The hematogenous metastases of colon cancer have primarily been explained by the cascade hypothesis based on the cadaveric study. However, we experienced several cases with isolated lung metastasis. The metastatic patterns of a total of 982 patients with colon cancer who underwent surgery were reviewed. The incidence ...

journal_title：Japanese journal of clinical oncology

authors： Sadahiro S,Suzuki T,Tanaka A,Okada K,Kamata H

更新日期：2013-04-01 00:00:00

abstract：:Technological progress in the field of cancer treatment can be expected to accelerate in the future, giving hope to such patients. At the same time, there is concern that cancer care will become more expensive. It is indispensable to minimize the economic burden of patients to deliver technological advances in treatme...

journal_title：Japanese journal of clinical oncology

authors： Koinuma N

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify problems experienced by psychologists involved in cancer and palliative care and consider an education system for psychologists. METHODS:We conducted a questionnaire survey of psychologists involved in cancer care and palliative care. At the 403 facilities, 419 psycholog...

journal_title：Japanese journal of clinical oncology

authors： Iwamitsu Y,Oba A,Hirai K,Asai M,Murakami N,Matsubara M,Kizawa Y

更新日期：2013-03-01 00:00:00

abstract：:Cancer is the leading cause of mortality in Singapore. The age-standardized incidence rates continue to increase as the population grows and ages, and the influence of environmental and lifestyle choices bear their consequences. The increase is most marked in colorectal, breast and prostate cancers, mirroring the most...

journal_title：Japanese journal of clinical oncology

authors： Teo MC,Soo KC

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:As clinical trials for limited-disease small-cell lung cancer often exclude elderly patients due to comorbidities and a decline in organ function, the most suitable treatment for limited-disease small-cell lung cancer patients aged 75 years or older still remains unclear. METHODS:From July 2002 to June 2011...

journal_title：Japanese journal of clinical oncology

authors： Shukuya T,Takahashi T,Harada H,Ono A,Akamatsu H,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Takahashi K,Yamamoto N

更新日期：2013-02-01 00:00:00

abstract：:This is a review regarding the current therapeutic strategies in the management of multiple myeloma. Due to the introduction of several new effective therapeutic agents, multiple myeloma is one of the most active and changing fields in clinical oncology. Multiple myeloma is caused by the expansion of monoclonal plasma...

journal_title：Japanese journal of clinical oncology

authors： Suzuki K

更新日期：2013-02-01 00:00:00

abstract：:Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhance...

journal_title：Japanese journal of clinical oncology

authors： Fukami Y,Kurumiya Y,Mizuno K,Sekoguchi E,Kobayashi S,Ito A,Tomida A,Onishi S,Shirotsuki R,Okubo K,Narita M

更新日期：2013-01-01 00:00:00

abstract：:A prospective multicenter trial has been started in Korea to investigate the treatment efficacy of a levonorgestrel-releasing intrauterine system plus medroxyprogesterone acetate in young women with early-stage endometrial cancer. A number of studies have reported the effectiveness of hormonal therapy using systemic p...

journal_title：Japanese journal of clinical oncology

authors： Kim MK,Seong SJ,Lee TS,Kim JW,Nam BH,Hong SR,Suh KS

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

journal_title：Japanese journal of clinical oncology

authors： Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

更新日期：2012-12-01 00:00:00

abstract：:Cancer causes profound suffering for patients, and previous reports have demonstrated that psychological distress, particularly depression, is frequently observed in advanced and/or terminally ill cancer patients. Such depression can lead to serious and far-reaching negative consequences in patients with advanced canc...

journal_title：Japanese journal of clinical oncology

authors： Akechi T

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the risk factors for sentinel lymph node metastasis and validate the value of the Memorial Sloan-Kettering Cancer Center nomogram for the prediction of sentinel lymph node metastasis in breast cancer patients. METHODS:A sentinel lymph node biopsy database containing 1227 consecutive breast cancer...

journal_title：Japanese journal of clinical oncology

authors： Qiu PF,Liu JJ,Wang YS,Yang GR,Liu YB,Sun X,Wang CJ,Zhang ZP

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify clinicopathological variables associated with the clinical outcomes of patients with lymph node metastasis-positive urothelial bladder carcinoma after radical cystectomy. METHODS:Forty-six patients who underwent radical cystectomy without preoperative chemotherapy and ha...

journal_title：Japanese journal of clinical oncology

authors： Nakagawa T,Kanai Y,Nakanishi H,Komiyama M,Fujimoto H

更新日期：2012-11-01 00:00:00

abstract：:There have been no reports describing acute exacerbations of idiopathic pulmonary fibrosis after particle radiotherapy for non-small cell lung cancer. The present study describes the case of a 76-year-old Japanese man with squamous cell carcinoma of the lung that relapsed in the left upper lobe 1 year after right uppe...

journal_title：Japanese journal of clinical oncology

authors： Nagano T,Kotani Y,Fujii O,Demizu Y,Niwa Y,Ohno Y,Nishio W,Itoh T,Murakami M,Nishimura Y

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Oral fluoropyrimidine plus cisplatin is a standard treatment for advanced gastric cancer, but patients with severe peritoneal metastasis often cannot tolerate this regimen. The aim of this study was to assess the feasibility of fluorouracil, l-leucovorin and paclitaxel therapy in such patients. METHODS:In th...

journal_title：Japanese journal of clinical oncology

authors： Iwasa S,Goto M,Yasui H,Nishina T,Takahari D,Nakayama N,Taira K,Kusaba H,Fuse N,Hironaka S,Shimada Y,Nakajima TE

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Long-term survival and late toxicities of a randomized Phase II study of chemoradiotherapy for esophageal cancer were analyzed. METHODS:Eligible patients were <75 years old and performance status 0-2, and had Stages II-IVA esophageal cancer. For arm A (short-term infusion), cisplatin 70 mg/m(2) Days 1 and 29...

journal_title：Japanese journal of clinical oncology

authors： Nishimura Y,Hiraoka M,Koike R,Nakamatsu K,Itasaka S,Kawamura M,Negoro Y,Araki N,Ishikawa H,Fujii T,Mitsuhashi N

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:The value of postmastectomy radiation therapy for breast cancer patients with T1-2 tumor and one to three positive nodes remains controversial. The purpose of this retrospective study was to compare the clinical outcomes of breast cancer patients with T1-2 and one to three positive nodes with and without post...

journal_title：Japanese journal of clinical oncology

authors： Huang CJ,Hou MF,Chuang HY,Lian SL,Huang MY,Chen FM,Fu OY,Lin SF

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Oesophageal squamous cell carcinoma is one of the deadliest malignancies worldwide. Contactin-1, a neural adhesion molecule, is implicated in tumour invasion and metastasis. The purpose of this study was to investigate the expression of CNTN-1 in normal and cancerous oesophageal tissue, and the potential rele...

journal_title：Japanese journal of clinical oncology

authors： Liu P,Chen S,Wu W,Liu B,Shen W,Wang F,He X,Zhang S

更新日期：2012-07-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor and is active against multiple myeloma. Most toxicities associated with bortezomib are mild to moderate and manageable; however, bortezomib-induced pneumonitis has been reported in some multiple myeloma cases. Bortezomib-induced pneumonitis was reported to occur relatively soon aft...

journal_title：Japanese journal of clinical oncology

authors： Yamaguchi T,Sasaki M,Itoh K

更新日期：2012-07-01 00:00:00

abstract：:A Phase II trial was initiated in Japan to evaluate the efficacy and safety of preoperative chemotherapy with docetaxel, cisplatin and S-1 for gastric cancer with extensive lymph node metastasis. Patients are eligible to participate in the study if they have para-aortic lymph node metastases (stations no. 16a2/16b1) a...

journal_title：Japanese journal of clinical oncology

authors： Katayama H,Ito S,Sano T,Takahari D,Mizusawa J,Boku N,Tsuburaya A,Terashima M,Sasako M,Stomach Cancer Study Group of the Japan Clinical Oncology Group.

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Apocrine carcinoma, a subtype of invasive ductal carcinoma of the breast, expresses androgen receptor (AR), but often lacks estrogen receptor (ER) and progesterone receptor (PgR). In the present study, the author immunohistochemically defined apocrine-type carcinoma as ER-/PgR-/AR+ invasive ductal carcinoma a...

journal_title：Japanese journal of clinical oncology

authors： Tsutsumi Y

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:We reviewed the relationship between extent of resection and survival of patients with high-grade gliomas with special consideration of an oligodendroglial component. METHODS:A retrospective review was performed on 160 adult patients with histological diagnosis of high-grade gliomas since 2000. All histologi...

journal_title：Japanese journal of clinical oncology

authors： Yamaguchi S,Kobayashi H,Terasaka S,Ishii N,Ikeda J,Kanno H,Nishihara H,Tanaka S,Houkin K

更新日期：2012-04-01 00:00:00

abstract：:The patient was a 9-year-old premenarcheal pediatric female, whose chief complaint was a well-circumscribed palpable right breast mass without nipple discharge. Although the patient had noticed the lump 2 years prior to hospital admission, its size (1.5 × 1.3 cm) had been stable. There was no family history or previou...

journal_title：Japanese journal of clinical oncology

authors： Yorozuya K,Takahashi E,Kousaka J,Mouri Y,Yoshida M,Fujii K,Akizuki M,Nakano S,Fukutomi T,Umemoto Y,Yokoi T,Imai H

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:The importance of quality assurance in cancer screening has recently gained increasing attention in Japan. To evaluate and improve quality, checklists and process indicators have been developed. To explore effective methods of enhancing quality in cancer screening, we started a randomized control study of the...

journal_title：Japanese journal of clinical oncology

authors： Machii R,Saika K,Higashi T,Aoki A,Hamashima C,Saito H

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Although cigarette smoking is considered as an important risk factor for esophageal cancer, the magnitude of the association might be varied among geographic areas. Therefore, we reviewed epidemiologic studies on the association between cigarette smoking and esophageal cancer among the Japanese population. M...

journal_title：Japanese journal of clinical oncology

authors： Oze I,Matsuo K,Ito H,Wakai K,Nagata C,Mizoue T,Tanaka K,Tsuji I,Tamakoshi A,Sasazuki S,Inoue M,Tsugane S,Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.

更新日期：2012-01-01 00:00:00

abstract：:A combined ischiopubic rami resection is extremely rare in the field of gastroenterologic surgery. We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver...

journal_title：Japanese journal of clinical oncology

authors： Uehara K,Yoshioka Y,Taguchi Y,Igami T,Ebata T,Yokoyama Y,Sugawara G,Tsukushi S,Nishida Y,Yoshino Y,Nagino M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Higher levels of physical activity have been consistently associated with a decreased risk of colon cancer, but not rectal cancer, in Western populations. The present study systematically evaluated epidemiologic evidence on the association between physical activity and colorectal cancer risk among the Japanes...

journal_title：Japanese journal of clinical oncology

authors： Pham NM,Mizoue T,Tanaka K,Tsuji I,Tamakoshi A,Matsuo K,Ito H,Wakai K,Nagata C,Sasazuki S,Inoue M,Tsugane S,Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.

更新日期：2012-01-01 00:00:00

abstract：:The Radiation Therapy Study Group (RTSG) of the Japan Clinical Oncology Group (JCOG) was established in 2003. The missions of this group are to develop new standards of care with innovative, advanced technology radiation therapy, both for single- and multi-modality cancer treatment, and to improve radiation therapy qu...

journal_title：Japanese journal of clinical oncology

authors： Ishikura S,Ito Y,Hiraoka M

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Suboptimal treatment of chemotherapy-induced nausea and vomiting and unsatisfactory response to antiemetic drugs cause impairment of cancer patient's daily functioning. This study was aimed to investigate the association of selected germline polymorphisms with ondansetron and metoclopramide response in Indone...

journal_title：Japanese journal of clinical oncology

authors： Perwitasari DA,Wessels JA,van der Straaten RJ,Baak-Pablo RF,Mustofa M,Hakimi M,Nortier JW,Gelderblom H,Guchelaar HJ

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Communicating the discontinuation of anticancer treatment to patients is a difficult task. The primary aim of this study was to clarify the level of oncologist-reported burden when communicating about discontinuation of an anticancer treatment. The secondary aims were (i) to identify the sources of burden con...

journal_title：Japanese journal of clinical oncology

authors： Otani H,Morita T,Esaki T,Ariyama H,Tsukasa K,Oshima A,Shiraisi K

更新日期：2011-08-01 00:00:00